Preclinical work in mice has demonstrated that Senvera's ASO activates HBCs and Creates Neurogenic Foci That Produce Many Neurons, Creating a Therapeutic Force Multiplier
P63 is a transcription factor that inhibits HBC differentiation
At Senvera Therapeutics, our approach centers on a deep foundational understanding of the molecular mechanisms that regulate peripheral olfactory stem cells.
We constantly lose olfactory neurons due to a number of causes including aging and viral infection.
A population of stem cells named Globose Basal Cells (GBCs) regenerates the olfactory neurons.
Eventually we lose Globose Basal Cells (GBCs) which halts the regeneration of olfactory neurons and results in smell loss.
A second population of stem cells named Horizontal Basal Cells (HBCs) have the potential to regenerate olfactory neurons, but fail to do so because they are locked in a dormant state.
We are developing genetic medicines to activate HBCs to regenerate olfactory neurons and restore smell and taste.
Our Science
Neuroregenerative genetic medicines to restore smell and taste
Targeted Molecular Innovation
Targeted Molecular Innovation
Targeting p63 can activate dormant HBCs to repair olfactory epithelium (OE) and restore olfaction
Targeting p63 can activate dormant HBCs to regenerate olfactory neurons and restore smell and taste
